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Cancer involves uncontrolled cell growth that can form malignant tumors capable of invading and spreading.
Uncontrolled cell growth and tumor invasion describe how cancer develops when cells proliferate without proper regulation and form malignant tumors. These malignant tumors can invade nearby tissues and, through metastasis, spread to other parts of the body. This distinguishes cancer from benign tumors, which do not spread. Tumor invasion and spread occur through a stepwise process that includes local invasion, entry of cancer cells into blood or lymphatic vessels (intravasation), circulation, exit into new tissues (extravasation), proliferation, and angiogenesis (formation of new blood vessels). Metastasis is common in later stages and is a major reason most cancer deaths occur, with frequent metastatic sites including the lungs, liver, brain, and bones.
Cancer involves uncontrolled cell growth that can form malignant tumors capable of invading and spreading.
Malignant tumors differ from benign tumors because they can metastasize to other body sites.
Metastasis typically follows stages: local invasion, intravasation, circulation, extravasation, proliferation, and angiogenesis.
Most cancer deaths are associated with metastasis, and common metastatic locations include lungs, liver, brain, and bones.
Abnormal cell proliferation that occurs when cells do not follow normal regulatory controls, enabling tumor formation.
The ability of malignant tumor cells to penetrate and damage surrounding tissues.
A cancerous tumor that can invade nearby tissues and spread to other parts of the body.
A non-cancerous tumor that does not invade or spread to other body sites.
The spread of cancer from a primary tumor to distant locations in the body, forming metastatic tumors.
The step in metastasis where cancer cells enter blood or lymphatic vessels.
The step in metastasis where cancer cells exit blood or lymphatic vessels into new tissue.
The formation of new blood vessels that helps tumors grow and support further spread.
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