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The cerebral cortex (also called the cerebral mantle) is the outer layer of neural tissue covering the cerebral hemispheres in humans and other mammals. It is the brain’s largest site of neural integration and is essential for higher functions including attention, perception, awareness, thought, memory, language, and consciousness. The cortex is divided into left and right hemispheres by the longitudinal fissure, and the hemispheres are connected beneath the cortex by the corpus callosum and other commissural fibers. Structurally, the cortex is folded into gyri (ridges) and sulci (grooves), which increase surface area and help organize brain circuitry within the skull. The majority of the cortex is the six-layered neocortex (about 90%), while the remaining portion is allocortex with three or four layers. Neurons are organized both horizontally into layers and vertically into microcircuits such as cortical columns and minicolumns. Functionally, different cortical areas specialize—for example, the motor cortex supports movement, the visual cortex supports sight, and association areas integrate information across domains.
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