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Cancer involves uncontrolled cell growth that can form malignant tumors capable of invasion and spread.
Uncontrolled cell growth and tumor invasion are defining features of cancer. Cancer is a group of diseases in which cells grow without proper regulation, forming malignant tumors that can invade nearby tissues and potentially spread to other parts of the body (metastasis). Malignant tumors differ from benign tumors because they have the ability to invade and disseminate. Tumor invasion is closely tied to metastasis, the process by which cancer spreads. Metastasis typically involves local invasion, entry of cancer cells into blood or lymph vessels (intravasation), circulation through the body, exit into new tissue (extravasation), and then proliferation with new blood supply (including angiogenesis). Because most cancer deaths are due to metastatic disease, invasion and spread are major drivers of cancer severity and outcomes.
Cancer involves uncontrolled cell growth that can form malignant tumors capable of invasion and spread.
Malignant tumors invade surrounding tissues, unlike benign tumors which do not spread.
Metastasis follows a stepwise process: local invasion, intravasation, circulation, extravasation, proliferation, and angiogenesis.
Most cancer-related deaths occur when cancer has metastasized.
A cancerous tumor that can invade nearby tissues and spread to other parts of the body.
The ability of malignant tumor cells to penetrate and damage surrounding tissues.
The spread of cancer from the primary tumor to distant sites in the body, forming metastatic tumors.
The original tumor where cancer begins.
The step in metastasis where cancer cells enter blood or lymph vessels.
The step in metastasis where cancer cells exit blood or lymph vessels into new tissue.
The formation of new blood vessels that supports tumor growth during metastasis.
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