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Leukemia typically originates in the bone marrow, producing large numbers of abnormal, immature blasts that displace normal blood cell production.
Leukemia is a group of blood cancers that usually begin in the bone marrow, where abnormal blood-forming cells proliferate. These cells are not fully developed and are called blasts (or leukemia cells). As they accumulate, they crowd out normal bone marrow function, leading to reduced production of healthy blood cells and causing symptoms such as bleeding/bruising, fatigue, fever, and increased risk of infections. The origin of leukemia is described as involving both inherited (genetic) and environmental (non-inherited) factors. While the exact cause is often unknown, leukemia results from DNA mutations that disrupt normal control of cell death, differentiation, and division. These mutations may occur spontaneously or be triggered by exposures such as ionizing radiation and certain chemicals (e.g., benzene), and risk can also be increased by conditions like Down syndrome and prior chemotherapy.
Leukemia typically originates in the bone marrow, producing large numbers of abnormal, immature blasts that displace normal blood cell production.
Leukemia develops due to DNA mutations influenced by inherited predisposition and environmental exposures, including radiation and certain chemicals.
The bone marrow is the blood-forming tissue where leukemia typically begins and where abnormal blasts crowd out normal blood cell production.
Blasts are immature blood cells produced in leukemia that are not fully developed and accumulate in the bone marrow and blood.
Changes in DNA that can activate oncogenes or disable tumor suppressor genes, driving uncontrolled cell growth in leukemia.
High-energy radiation exposure that is a known risk factor for developing leukemia.
A chemical exposure (a petrochemical) associated with increased leukemia risk, particularly for some myeloid leukemias.
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