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Vitamin D increases intestinal absorption of calcium and phosphate, supporting calcium/phosphate balance and bone health.
Vitamin D is a group of fat-soluble compounds (mainly vitamin D3/cholecalciferol and vitamin D2/ergocalciferol) that increase intestinal absorption of calcium and phosphate, which is essential for maintaining normal blood mineral levels and supporting bone health. In the body, vitamin D is converted in the liver to calcifediol (25-hydroxyvitamin D, measured as 25(OH)D) and then further hydroxylated in the kidneys (and some immune cells) to calcitriol (1,25-dihydroxyvitamin D), the biologically active form. Calcitriol exerts its effects by binding to the vitamin D receptor (VDR), a nuclear receptor that regulates gene expression. When calcitriol binds the VDR, it modulates the transcription of transport proteins involved in mineral absorption in the intestine (such as TRPV6 and calbindin), thereby enhancing calcium and phosphate uptake. This VDR-mediated regulation in the intestine, along with coordinated roles in bone, kidney, and parathyroid function, helps maintain calcium and phosphorus balance in the blood and contributes to healthy bone mineralization.
Vitamin D increases intestinal absorption of calcium and phosphate, supporting calcium/phosphate balance and bone health.
Vitamin D3 and D2 are converted to calcifediol (25(OH)D) and then to calcitriol (1,25(OH)2D), the active hormone.
Calcitriol binds the vitamin D receptor (VDR) and alters gene expression of intestinal transport proteins (e.g., TRPV6, calbindin) that promote calcium absorption.
The biologically active vitamin D metabolite that binds the vitamin D receptor to regulate calcium and phosphate absorption.
The major circulating vitamin D metabolite measured in serum to assess vitamin D status.
A nuclear receptor that, when activated by calcitriol, functions as a transcription factor to modulate genes involved in intestinal mineral transport.
An intestinal calcium transport protein whose expression is regulated by VDR activation to enhance calcium absorption.
An intracellular calcium-binding protein in the intestine that supports calcium transport and is regulated by VDR signaling.
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